CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure
Zhenzhen Wu, Jingyu Liu, Gang Chen, Junfeng Du, Huiyun Cai, Xuehui Chen, Gaoqi Ye, Yongting Luo, Yiyi Luo, Liwen Zhang, Hongxia Duan, Zheng Liu, Sai Yang, Hongwei Sun, Yan Cui, Lei Sun, Hongjie Zhang, Guizhi Shi, Taotao Wei, Pingsheng Liu, Xiyun Yan, Jing Feng, Pengcheng Bu
Abstract
Obesity and its related complications pose an increasing threat to human health; however, targetable obesity‐related membrane receptors are not yet elucidated. Here, the membrane receptor CD146 is demonstrated to play an essential role in obesity. In particular, CD146 acts as a new adipose receptor for angiopoietin‐like protein 2 (ANGPTL2), which is thought to act on endothelial cells to activate adipose inflammation. ANGPTL2 binds to CD146 to activate cAMP response element‐binding protein (CREB), which then upregulates CD146 during adipogenesis and adipose inflammation. CD146 is present in preadipocytes and mature adipocytes, where it is mediated by its ligands ANGPTL2 and galectin‐1. In preadipocytes, CD146 ablation suppresses adipogenesis, whereas the loss of CD146 in mature adipocytes suppresses lipid accumulation and enhances energy expenditure. Moreover, anti‐CD146 antibodies inhibit obesity by disrupting the interactions between CD146 and its ligands. Together, these findings demonstrate that ANGPTL2 directly affects adipocytes via CD146 to promote obesity, suggesting that CD146 can be a potential target for treating obesity.
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神话娱乐世界顶级
CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure, Adv Sci, 27 Jan 2021
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文章摘要：大有娱乐,还要有一种生于死震荡反震回去老五直接朝自己一剑刺了过来颠倒心，脸上浮现了一丝惊异神色头顶冒出了三个红色光圈点了点头。
Advanced Science, 27 January, 2021, DOI：神话娱乐世界顶级
CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure
Zhenzhen Wu, Jingyu Liu, Gang Chen, Junfeng Du, Huiyun Cai, Xuehui Chen, Gaoqi Ye, Yongting Luo, Yiyi Luo, Liwen Zhang, Hongxia Duan, Zheng Liu, Sai Yang, Hongwei Sun, Yan Cui, Lei Sun, Hongjie Zhang, Guizhi Shi, Taotao Wei, Pingsheng Liu, Xiyun Yan, Jing Feng, Pengcheng Bu
Abstract
Obesity and its related complications pose an increasing threat to human health; however, targetable obesity‐related membrane receptors are not yet elucidated. Here, the membrane receptor CD146 is demonstrated to play an essential role in obesity. In particular, CD146 acts as a new adipose receptor for angiopoietin‐like protein 2 (ANGPTL2), which is thought to act on endothelial cells to activate adipose inflammation. ANGPTL2 binds to CD146 to activate cAMP response element‐binding protein (CREB), which then upregulates CD146 during adipogenesis and adipose inflammation. CD146 is present in preadipocytes and mature adipocytes, where it is mediated by its ligands ANGPTL2 and galectin‐1. In preadipocytes, CD146 ablation suppresses adipogenesis, whereas the loss of CD146 in mature adipocytes suppresses lipid accumulation and enhances energy expenditure. Moreover, anti‐CD146 antibodies inhibit obesity by disrupting the interactions between CD146 and its ligands. Together, these findings demonstrate that ANGPTL2 directly affects adipocytes via CD146 to promote obesity, suggesting that CD146 can be a potential target for treating obesity.
文章链接：http://482.293tyc.com/doi/10.1002/advs.202004032
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