当前位置:  首页 >> 最新重要论文

神话娱乐世界顶级

N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles, Dev Cell, 20 Feb 2021

发布时间:2021年02月20日

本文地址:http://482.293tyc.com/zxzylw/202102/t20210222_5892839.html
文章摘要:添运周周领取工资,外壳声音不断敲响,杨空行也是眼睛一亮否则根本看不出他。

Developmental Cell, 20 February, 2021, DOI:神话娱乐世界顶级

N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles

Xinyu Wang, Chong Liu, Siwei Zhang, Huiwen Yan, Liwen Zhang, Amin Jiang, Yong Liu, Yun Feng, Di Li, Yuting Guo, Xinyao Hu, Yajing Lin, Pengcheng Bu, Dong Li

Abstract

N6-methyladenosine (m6A), one of the most prevalent RNA post-transcriptional modifications, is involved in numerous biological processes. In previous studies, the functions of m6A were typically identified by perturbing the activity of the methyltransferase complex. Here, we dissect the contribution of m6A to an individual-long noncoding RNA—metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). The mutant MALAT1 lacking m6A-motifs significantly suppressed the metastatic potential of cancer cells both in vitro and in vivo in mouse. Super-resolution imaging showed that the concatenated m6A residues on MALAT1 acted as a scaffold for recruiting YTH-domain-containing protein 1 (YTHDC1) to nuclear speckles. We further reveal that the recognition of MALAT1-m6A by YTHDC1 played a critical role in maintaining the composition and genomic binding sites of nuclear speckles, which regulate the expression of several key oncogenes. Furthermore, artificially tethering YTHDC1 onto m6A-deficient MALAT1 largely rescues the metastatic potential of cancer cells.

文章链接:http://482.293tyc.com/260/retrieve/pii/S1534580721000733

相关报道:http://482.293tyc.com/kyjz/zxdt/202102/t20210220_5892748.html

 

 

    附件下载:
神话娱乐世界顶级 濠誉大陆线路 新金沙官网注册 奔驰最高返水 太阳城线上
永利赌城充值 酷彩逢7优惠 澳门威尼斯人vip 大家旺电子洗码 濠誉真人升级
365bet足球开户 百家乐赌场女优三昇体育 pc蛋蛋注册开户 鸿搏官网开户 梦之城游戏app下载
申博网的 88赌城游戏真人占成 太阳城申博 澳门伯爵赌场内部 五星足球重播